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Healing of Apicomarginal Defects Using Autograft or Allograft With Collagen Membrane
Sponsor: Postgraduate Institute of Dental Sciences Rohtak
Summary
Apicomarginal defects, which connect apical and marginal bone loss, are difficult to manage surgically due to their limited regenerative potential. Guided tissue regeneration using grafts and collagen membranes may improve outcomes, but the comparative effectiveness of autografts and allografts in these defects is not well established. This randomized clinical trial at PGIDS Rohtak will evaluate 36 patients undergoing endodontic microsurgery, assigning them to either autograft or allograft combined with a bioresorbable collagen membrane. Clinical and CBCT-based radiographic healing will be monitored over 12 months. The study aims to determine whether allografts can achieve bone regeneration comparable to autografts, offering a less invasive option for treating apicomarginal defects.
Official title: Comparative Evaluation of Autograft and Allograft With Collagen Membrane in the Healing of Apicomarginal Defects: A Parallel-Arm Randomized Clinical Trial
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2026-04-01
Completion Date
2026-12-01
Last Updated
2026-02-17
Healthy Volunteers
No
Conditions
Interventions
Guided tissue regeneration
All participants will undergo standardized endodontic microsurgery to manage apicomarginal defects. After flap reflection, defect debridement, root-end preparation, and retrograde filling, patients will be randomly assigned to one of two groups. Autograft + Collagen Membrane Group and Allograft + Collagen Membrane Group
Locations (1)
Post Graduate Institute of Dental Sciences, Rohtak
Rohtak, Haryana, India