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Proton Therapy for Recurrent Nasopharyngeal Carcinoma
Sponsor: Guangzhou Concord Cancer Center
Summary
The above studies show that most of the supportive evidence for the reduction of toxicity and improvement of efficacy of proton therapy for recurrent Nasopharyngeal carcinoma(NPC) comes from various observational and retrospective studies, lacking high-level evidence-based medical evidence. The conduct of this study will explore the safety and efficacy of intensity-modulated proton radiotherapy for recurrent NPC and provide more high-quality evidence-based medical evidence for proton therapy of recurrent cancer.
Official title: A Prospective Phase II Clinical Study of Proton Therapy for Recurrent Nasopharyngeal Carcinoma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
52
Start Date
2025-03-10
Completion Date
2028-03-10
Last Updated
2026-03-09
Healthy Volunteers
No
Conditions
Interventions
Proton therapy
Treatment planning and target delineation: All patients were in the supine position with the head extended backward, with the mask fixed, and enhanced computed tomography (CT) scans were performed for positioning. The slice thickness was 1.25mm. The gross tumor volume (GTV) included the recurrent primary lesion. The clinical target volume (CTV) included the anatomical expansion of the tumor and the suspicious lesions visible under the microscope. The CTV was defined as an expansion of 5-10mm outside the GTV. Radiation dose and treatment plan: The prescribed dose was 60-66 Gray (Gy) delivered in 30-33 fractions. Plan design and dose verification: The physicist designed radiotherapy plans according to the requirements of the physician. After the radiotherapy plan was designed, it was evaluated and repeatedly optimized by the physician and the physicist until satisfactory results were achieved. Treatment: was required for each treatment session.
Proton radiation therapy
Radiation: Proton Therapy System (ProBeam)
Locations (2)
Guangzhou Concord Cancer Center
Guangzhou, Guangdong, China
Guangzhou concord cancer center
Guanzhou, Guangzhou, China