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A Study of BMS-986528 in Participants With Refractory Rheumatoid Arthritis
Sponsor: Bristol-Myers Squibb
Summary
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and the preliminary evidence of disease-modifying effect of BMS-986528 in participants with refractory, difficult-to-treat rheumatoid arthritis (RA).
Official title: A Phase 1/2a, Open-label, First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of BMS-986528 in Participants With Refractory Rheumatoid Arthritis
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
84
Start Date
2026-05-28
Completion Date
2030-09-02
Last Updated
2026-02-23
Healthy Volunteers
No
Conditions
Interventions
BMS-986528
Specified dose on specified days
Locations (31)
Local Institution - 0050
Aurora, Colorado, United States
Local Institution - 0055
South Miami, Florida, United States
Local Institution - 0066
Portland, Oregon, United States
Local Institution - 0051
DeSoto, Texas, United States
Local Institution - 0057
San Antonio, Texas, United States
Local Institution - 0048
Merksem, Flanders, Belgium
Local Institution - 0049
Leuven, Belgium
Local Institution - 0006
Beijing, Beijing Municipality, China
Local Institution - 0010
Zhengzhou, Henan, China
Local Institution - 0007
Nanchang, Jiangxi, China
Local Institution - 0020
Shanghai, Shanghai Municipality, China
Local Institution - 0001
Shanghai, Shanghai Municipality, China
Local Institution - 0040
München, Bavaria, Germany
Local Institution - 0056
Sendenhorst, North Rhine-Westphalia, Germany
Local Institution - 0022
Berlin, Germany
Local Institution - 0021
Cologne, Germany
Local Institution - 0028
Herne, Germany
Local Institution - 0065
Potsdam, Germany
Local Institution - 0045
Budapest, Hungary
Local Institution - 0019
Rozzano, Milano, Italy
Local Institution - 0017
Roma, Italy
Local Institution - 0023
Józefów, Masovian Voivodeship, Poland
Local Institution - 0039
A Coruña, A Coruña [La Coruña], Spain
Local Institution - 0058
Córdoba, Córdoba, Spain
Local Institution - 0037
Bern, Switzerland
Local Institution - 0027
Geneva, Switzerland
Local Institution - 0060
Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine
Local Institution - 0064
Kyiv, Kyiv Oblast, Ukraine
Local Institution - 0063
Poltava, Poltava Oblast, Ukraine
Local Institution - 0062
Kyiv, Ukraine
Local Institution - 0061
Ternopil, Ukraine