Clinical Research Directory

Inclusion Criteria: * Age \>=18 years old * To be a free subject, without guardianship, curatorship or subordination. * To be affiliated with a Social Security scheme, or benefit from it through a third party. * Written Informed consent signed by the subject after receiving clear and honest information about the study. * Healthcare professionals include administrative and technical professionals working in the healthcare sector in the private, public or independent sectors. * Smoking at least 6 cigarettes per day for at least 6 months. * Being motivated to quit smoking Exclusion Criteria: * Unstabilized depression * Psychosis and/or cognitive impairment and/or mental retardation or chronic use of medication for these disorders, * Addictive comorbidity such as alcoholism or abuse of substances other than tobacco, * Persons benefiting from enhanced protection, namely minors, persons deprived of their liberty by judicial or administrative decision, persons staying in a health or social institution, and finally patients in emergency situations. * Roommates, spouses, or family members already included in the study (to avoid interference with treatment) * Contraindication to nicotine replacement therapy (NRT) * Use of medication to quit smoking (NRT, bupropion), cognitive behavioral therapy (CBT), hypnotherapy, acupuncture in the last 3 months * Use of an electronic cigarette to quit smoking in the last 3 months * Concurrent participation in another clinical research study until visit V4 of this study. MUSICAT-BIO Exclusion Criteria (ancillary study, 30 healthy volunteers): * Not be a smoker or former smoker, nor a vaper or former vaper (including nicotine-free vaping), * Chronic diseases, * Systemic corticosteroid treatment, * Anti-infective treatment in the previous 3 weeks (antibiotics, antivirals, antifungals, etc.), * Concurrent participation in another interventional clinical research study.