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A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies
Sponsor: Mirati Therapeutics Inc.
Summary
This is an open-label, solid tumor, continuation, rollover trial which enrolls participants from ongoing BMS parent studies that evaluated adagrasib (MRTX849, BMS-986503) either as monotherapy or in combination with other cancer therapies in patients with non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and other advanced solid tumors.
Official title: Solid Tumor Study for Long Term Treatment of Cancer Patients Who Have Participated in BMS Parent Studies Investigating Adagrasib (BMS-986503)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
170
Start Date
2026-05-06
Completion Date
2028-02-16
Last Updated
2026-10-09
Healthy Volunteers
No
Conditions
Interventions
Adagrasib
Specified dose on specified days
Pembrolizumab
Specified dose on specified days
Cetuximab
Specified dose on specified days
Pemetrexed
Specified dose on specified days
Docetaxel
Specified dose on specified days
Irinotecan
Specified dose on specified days
Leucovorin
Specified dose on specified days
Oxaliplatin
Specified dose on specified days
Fluorouracil
Specified dose on specified days
Locations (102)
Local Institution - 0005
Phoenix, Arizona, United States
Southern California Permanente Medical Group
Bellflower, California, United States
MemorialCare - Long Beach Medical Center
Long Beach, California, United States
Local Institution - 0003
Newark, Delaware, United States
Florida Cancer Specialists - North
St. Petersburg, Florida, United States
Cancer Center of Kansas
Wichita, Kansas, United States
Local Institution - 0092
Boston, Massachusetts, United States
Dana Farber Cancer Center
Boston, Massachusetts, United States
Mayo Clinic in Rochester, Minnesota
Rochester, Minnesota, United States
Metro-Minnesota Community Oncology Research Consortium (MMCORC)
Saint Paul, Minnesota, United States
Nebraska Cancer Specialists
Omaha, Nebraska, United States
Oncology Associates Of Oregon, Pc
Eugene, Oregon, United States
The West Clinic, PLLC dba West Cancer Center
Germantown, Tennessee, United States
Texas Oncology-Bedford
Bedford, Texas, United States
Texas Oncology - Baylor Charles A. Sammons Cancer Center
Dallas, Texas, United States
Texas Oncology - DFW
Grapevine, Texas, United States
PeaceHealth St. Joseph Medical Center
Bellingham, Washington, United States
Local Institution - 0093
St Leonards, New South Wales, Australia
AZ Maria Middelares
Ghent, Belgium
Local Institution - 0108
São Paulo, Brazil
Local Institution - 0111
São Paulo, Brazil
BC Cancer - Vancouver
Vancouver, British Columbia, Canada
Local Institution - 0037
Beijing, Beijing Municipality, China
Local Institution - 0045
Xiamen, Fujian, China
Local Institution - 0042
Zhengzhou, Henan, China
Local Institution - 0038
Changsha, Hunan, China
Local Institution - 0046
Nanjing, Jiangsu, China
Local Institution - 0048
Nanchang, Jiangxi, China
Local Institution - 0049
Shenyang, Liaoning, China
Local Institution - 0039
Jinan, Shandong, China
Local Institution - 0047
Linyi, Shandong, China
Local Institution - 0043
Shanghai, Shanghai Municipality, China
Local Institution - 0040
Chengdu, Sichuan, China
Local Institution - 0044
Hangzhou, Zhejiang, China
Local Institution - 0041
Xi'an, China
Local Institution - 0076
Nice, Alpes-Maritimes, France
Centre Antoine-Lacassagne
Nice, Alpes-Maritimes, France
Nouvel Hôpital Civil (NHC)
Strasbourg, Alsace, France
Local Institution - 0103
Pessac, Aquitaine, France
Chu Jean Minjoz
Besançon, Doubs, France
Local Institution - 0065
La Tronche, Isère, France
Local Institution - 0063
Saint-Herblain, Loire-Atlantique, France
Local Institution - 0050
Saint-Herblain, Loire-Atlantique, France
ICO Papin
Angers, Maine-et-Loire, France
Hospices Civils de Lyon - Hopital Louis Pradel
Bron, Rhône, France
Local Institution - 0075
Gleizé, Rhône, France
Local Institution - 0051
Poitiers, Vienne, France
Centre Hospitalier Intercommunal de Créteil
Créteil, France
Assistance Publique Hôpitaux de Marseille - Hôpital Nord
Marseille, France
Centre Hospitalier de Cornouaille Quimper - Concarneau
Quimper, France
Hôpital d'Instruction des Armées Bégin
Saint-Mandé, France
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
Tours, France
Local Institution - 0061
Paris, Île-de-France Region, France
Klinikum Neuperlach
München, Germany
Local Institution - 0081
Athens, Attikí, Greece
Local Institution - 0022
Attiki, Greece
Local Institution - 0087
Thessaloniki, Greece
Orszagos Koranyi Pulmonologiai Intezet
Budapest, Hungary
Orszagos Onkologiai Intezet
Budapest, Hungary
Local Institution - 0055
Jerusalem, Jerusalem, Israel
Local Institution - 0119
Haifa, Israel
Local Institution - 0106
Tel Aviv, Israel
Azienda Ospedaliero-Universitaria San Luigi Gonzaga
Orbassano, Piedmont, Italy
Istituto Nazionale Tumori Regina Elena
Rome, Roma, Italy
Azienda Ospedaliera Universitaria Careggi
Florence, Tuscany, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna, Italy
Local Institution - 0052
Meldola, Italy
Istituto Europeo di Oncologia IRCCS
Milan, Italy
Istituto Europeo di Oncologia IRCCS
Milan, Italy
Local Institution - 0079
Pesaro, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
Roma, Italy
Local Institution - 0026
Terni (Perugia), Italy
Local Institution - 0110
Tōon, Ehime, Japan
Local Institution - 0056
Breda, North Brabant, Netherlands
Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL)
Amsterdam, North Holland, Netherlands
Ziekenhuis St. Jansdal
Harderwijk, Netherlands
Local Institution - 0071
Utrecht, Netherlands
Uniwersyteckie Centrum Kliniczne-Early Clinical Trials Unit
Gdansk, Poland
Local Institution - 0014
Lisbon, Lisbon District, Portugal
Local Institution - 0060
Craiova, Dolj, Romania
National Cancer Centre Singapore
Singapore, Singapore
Local Institution - 0069
Goyang-si, Kyǒnggi-do, South Korea
Local Institution - 0070
Seoul, South Korea
Local Institution - 0068
Seoul, South Korea
CHUAC-Complejo Hospitalario Universitario A Coruña
A Coruña, A Coruña [La Coruña], Spain
Local Institution - 0011
Palma, Balears [Baleares], Spain
Local Institution - 0010
Barcelona, Barcelona [Barcelona], Spain
Institut Catala d'Oncologia-Hospital Germans Trias i Pujol
Badalona, Barcelona, Spain
Local Institution - 0030
Santander, Cantabria, Spain
Hospital Universitario Ramón y Cajal
Madrid, Madrid, Comunidad de, Spain
Clinica Universidad de Navarra
Pamplona, Navarre, Spain
Hospital Clinico de Valencia
Valencia, Valenciana, Comunitat, Spain
Local Institution - 0029
Barcelona, Spain
Hospital Universitario Reina Sofia
Córdoba, Spain
Hospital General Universitario Gregorio Marañon
Madrid, Spain
Hospital Universitario Fundacion Jimenez Diaz
Madrid, Spain
Local Institution - 0062
Madrid, Spain
H.R.U Málaga - Hospital General
Málaga, Spain
Local Institution - 0008
Seville, Spain
Local Institution - 0115
London, London, City of, United Kingdom
University Hospitals Birmingham NHS Foundation Trust - Heartlands Hospital
Birmingham, United Kingdom
Leicester Royal Infirmary-HOPE Clinical Trials Unit
Leicester, United Kingdom