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Ketogenic Diet for Post-Traumatic Stress Disorder (PTSD)
Sponsor: Bundeswehr University Munich
Summary
This project is a prospective, single-arm, open-label feasibility study testing whether a 12-week medically supervised ketogenic diet (KD) can be implemented in adults with PTSD in Germany (N=6). The primary aim is feasibility: recruitment (N=6 within a predefined timeframe), adherence to ketosis measured by daily capillary β-hydroxybutyrate (BHB), completion of study assessments (including daily EMA symptom/BHB reporting), and retention through the post-intervention visit. Secondary outcomes include participant self-reported feasibility at week 12. Exploratory outcomes include descriptive changes in PTSD symptoms/mental health and metabolic/inflammatory/mitochondrial biomarkers as well as associations between biomarkers and PTSD symptoms. The study is not powered for efficacy; results will inform the design of a larger clinical trial.
Official title: Ketogenic Diet in the Treatment of PTSD in Germany: A Single-Arm Feasibility Study
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
6
Start Date
2026-03-03
Completion Date
2026-07-13
Last Updated
2026-02-20
Healthy Volunteers
No
Conditions
Interventions
Ketogenic diet
Participants will undergo a medically supervised ketogenic dietary intervention, individually tailored to achieve and maintain low-level ketosis (β-hydroxybutyrate \[BHB\] concentrations typically ≥ 0.5 mmol/L) within two weeks. Depending on individual response and tolerability, participants may gradually adjust their dietary composition (e.g., by increasing the proportion of fat relative to protein and carbohydrates) to reach higher levels of ketosis (BHB typically ≥ 2.0 mmol/L) as an optional target. The dietary intervention will be guided and monitored by qualified dietitians under medical supervision.
Locations (2)
Hochschulambulanz der Universität der Bundeswehr München
München, Bavaria, Germany
LMU Klinikum (Klinik für Anästhesiologie)
München, Bavaria, Germany