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GCCC 2578 Randomized Photon vs Proton RT for Newly Diagnosed Gynecologic Primaries
Sponsor: University of Maryland, Baltimore
Summary
The purpose of study is to compare the side effects of two different forms of radiation for endometrial and cervical cancer. If you decide to enroll in this study, you will be randomized to one of two treatment groups. This study will compare two standard of care treatments: "Conventional" pHoton radiation versus pRoton radiation.
Official title: A Phase II, Randomized, Open-Label, Single-Center Study Comparing Intensity Modulated Proton Therapy Versus Volume Modulated Arc Therapy in Patients Receiving Pelvic Nodal Irradiation for Newly Diagnosed Gynecologic Primaries
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
116
Start Date
2026-03
Completion Date
2033-12
Last Updated
2026-02-17
Healthy Volunteers
No
Interventions
Volume Modulated Arc Therapy (VMAT)
VMAT RT- 45-50.4 Gy in 1.8-2 Gy fractions All patients will receive concurrent cisplatin 40 mg/m2 on a weekly basis during EBRT in accordance with standard of care. No chemotherapy will be utilized during HDR brachytherapy.
Intensity Modulated Proton Therapy (IMPT)
IMPT- 45-50.4 Gy in 1.8-2 Gy fractions All patients will receive concurrent cisplatin 40 mg/m2 on a weekly basis during EBRT in accordance with standard of care. No chemotherapy will be utilized during HDR brachytherapy.
Locations (5)
Maryland Proton Treatment Center
Baltimore, Maryland, United States
University of Maryland Greenebaum Cancer Center
Baltimore, Maryland, United States
Upper Chesapeake Health
Bel Air, Maryland, United States
Central Maryland Radiation Oncology
Columbia, Maryland, United States
Baltimore Washington Medical Center- Tate Cancer Center
Glen Burnie, Maryland, United States