Clinical Research Directory

Inclusion Criteria: * Age 18-65 years. * Body Mass Index (BMI) ≥ 24.0 kg/m² or meeting the criteria for central obesity (waist circumference ≥ 90 cm for men, ≥ 85 cm for women); participants with mild abnormalities in blood lipids and liver function indicators will be prioritized. * Permanent residents of the local area during the trial period, with no plans for long-term business trips or travel. * Fully understand the research content and voluntarily sign the informed consent form. Exclusion Criteria: * Diagnosed congenital or acquired immunodeficiency diseases, severe allergic diseases, active gastrointestinal diseases, and other acute or chronic diseases requiring long-term treatment. * Use of antibiotics, immunosuppressants, probiotics, prebiotics, synbiotics, or other drugs that clearly affect gut microbiota or gastrointestinal function within the 6 months prior to the trial. * Regular intake of nutritional supplements (such as vitamins, fish oil, etc.) within the 6 months prior to the trial. * Having bad lifestyle habits such as smoking or alcoholism. * Women who are pregnant, lactating, or planning to become pregnant. * Weight change exceeding 5% of body weight within the 3 months prior to the trial. * Participation in or planning to participate in any other clinical intervention studies.