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Effect of Maternal Chocolate Consumption on Fetal Non-Stress Test (NST) Reactivity.
Sponsor: Universidad Nacional Autonoma de Honduras
Summary
This is a single-blind, randomized, parallel-group, superiority clinical trial. The study aims to determine whether a single intake of 30g of dark chocolate (≥80% cocoa) by pregnant women with a non-reactive fetal non-stress test (NST) increases the conversion rate to a reactive NST within 20 minutes, compared to observation with a sugar-free white chocolate placebo. A total of 190 singleton pregnant women at 36-41 weeks gestation with a non-reactive NST will be recruited at the Hospital General San Felipe, Tegucigalpa, Honduras. Participants will be randomly assigned to either the intervention group (dark chocolate) or the control group (placebo). The primary outcome is the proportion of NSTs that become reactive. Secondary outcomes include changes in specific cardiotocographic parameters, total monitoring time, need for additional tests, and maternal satisfaction.
Official title: Effect of Maternal Consumption of Dark Chocolate on the Reactivity of the Fetal Non-Stress Test (NST): A Single-Blind, Randomized Clinical Trial.
Key Details
Gender
FEMALE
Age Range
18 Years - 49 Years
Study Type
INTERVENTIONAL
Enrollment
190
Start Date
2026-02-15
Completion Date
2026-09-30
Last Updated
2026-03-03
Healthy Volunteers
Yes
Conditions
Interventions
Dark Chocolate
Single oral dose of 30g of dark chocolate (minimum 80% cocoa content). Consumed within 5 minutes after a baseline non-reactive NST.
Sugar-free White Chocolate
Single oral dose of 30g of sugar-free white chocolate, administered similarly. Serves as a placebo control without significant theobromine/caffeine.
Locations (1)
Hospital San Felipe
Tegucigalpa, Francisco Morazán Department, Honduras