Clinical Research Directory

Inclusion Criteria: * Non-walkers with an SCI greater than 3 years post injury * As measured by a member of the study staff, participants who have a lower extremity motor score greater or equal to 16 on the INSCSCI exam with an impairment grade of C or D * Neurologic level of injury as determined by study staff between C5-T10 (completed at participant's screening) * Capable of gripping Lofstrand crutches and/or a walker without assistance * Wheelchair reliant 100% of the time * Height is between 62 inches and 74 inches * Weight less than 220lbs * Anthropometric compatibility with the EAW device: * Thigh length between 14 and 19 in (36 and 48 cm) * Shank length between 17 and 22 in (43 and 55 cm) Exclusion Criteria: * As determined by the study physician from the screening health exam, a history of fragility or traumatic fractures, unhealed fractures, and signs of swelling, bruising, and discoloration of the legs * Current bone disease diagnosis (e.g., osteomyelitis, hyperparathyroidism) * As determined by the study physician from the screening DXA study, a T-score at the total hip \< -3.5 or aBMD of the knee (proximal tibia and/or distal femur) \< 0.60 g/cm2 from the DXA screen * Positive pregnancy test at any of the study intervention or assessment visits, or if female participants plan to become pregnant over the course of the study, they will be excluded or withdrawn (if already enrolled) from participation * Currently in a gym/rehabilitation program performing ambulatory interventions such as EAW, as determined by the study staff * Currently prescribed any medications that can affect muscle and/or bone metabolism, as determined by the study staff Exclusion Criteria from MRI Safety Screening: * Medically unsafe to receive an MRI scan * Claustrophobia * Baclofen pump * Body metal, including any of the following: * metal fragments or pieces in eyes or any other part of body * pacemakers or other implanted electrical devices * aneurysm clips (metal clips on wall of a large artery) * metallic prostheses (metal pins and heart valves) * internal hearing aids (cochlear implants) * permanent eyeliner * shrapnel fragments * piercing that cannot be removed