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Pressure Targeting During High Flow Therapy in Premature Infants
Sponsor: University of Texas at Austin
Summary
The goal of this study is to see if a new approach to breathing support ('Pressure Targeted High Flow') is as effective as standard of care ('Continuous Positive Airway Pressure') in prematurely born infants. It will also learn about the effect of these types of breathing support on infant comfort and impact on staffing. The main question it aims to answer is: Does Pressure Targeted High Flow provide enough support in premature infants? Participants will: Take spend 24 hours supported by Pressure Targeted High Flow and 24 hours supported by CPAP. During this time their breathing rate, oxygen requirement and other markers of comfort will be monitored.
Official title: A Phase 2 Crossover Trial of Pressure Targeted High Flow Therapy in Premature Infants
Key Details
Gender
All
Age Range
7 Days - 40 Weeks
Study Type
INTERVENTIONAL
Enrollment
78
Start Date
2026-05-01
Completion Date
2027-09
Last Updated
2026-02-18
Healthy Volunteers
No
Interventions
Pressure Targeted High Flow
High Flow Nasal Cannula therapy with Pressure monitoring to match delivered CPAP pressure
CPAP
Standard of care CPAP therapy
Locations (2)
Sharp Mary Birch Hospital for Women & Newborns
San Diego, California, United States
Ascension Seton Medical Center
Austin, Texas, United States