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RECRUITING
NCT07418593
PHASE4

THE MALABSORPTION BLOOD TEST TRIAL WILL HELP DETERMINE THE BENEFITS OF PANCREATIC ENZYME REPLACEMENT THERAPY IN PATIENTS WITH MILD TO MODERATE EXOCRINE PANCREATIC INSUFFICIENCY.

Sponsor: Anna Evans Phillips

View on ClinicalTrials.gov

Summary

This project uses the Malabsorption Blood Test (MBT) to identify patients with recurrent acute or chronic pancreatitis who have mild to moderate exocrine pancreatic insufficiency. A subgroup of patients who have response to pancreatic enzyme replacement therapy will enter a randomized, placebo-controlled pilot clinical trial for 8 weeks to identify improvements in quality of life (QOL).

Official title: Malabsorption Blood Test (MBT) to Determine Exocrine Pancreatic Function and Related Quality of Life in Chronic Pancreatitis

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

80

Start Date

2026-03

Completion Date

2028-09

Last Updated

2026-02-18

Healthy Volunteers

No

Interventions

DRUG

Pancreatic Enzyme Replacement Therapy

12 participants who are PERT responders in the MBT will be randomized to receive 8 weeks of PERT (144,000 lipase units daily)

DRUG

Placebo

12 participants who are PERT responders in the MBT will be assigned to receive 8 weeks of placebo therapy

DIAGNOSTIC_TEST

MBT1

MBT off PERT

DIAGNOSTIC_TEST

MBT 2

MBT on PERT

Locations (2)

Johns Hopkins Medicine

Baltimore, Maryland, United States

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States