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THE MALABSORPTION BLOOD TEST TRIAL WILL HELP DETERMINE THE BENEFITS OF PANCREATIC ENZYME REPLACEMENT THERAPY IN PATIENTS WITH MILD TO MODERATE EXOCRINE PANCREATIC INSUFFICIENCY.
Sponsor: Anna Evans Phillips
Summary
This project uses the Malabsorption Blood Test (MBT) to identify patients with recurrent acute or chronic pancreatitis who have mild to moderate exocrine pancreatic insufficiency. A subgroup of patients who have response to pancreatic enzyme replacement therapy will enter a randomized, placebo-controlled pilot clinical trial for 8 weeks to identify improvements in quality of life (QOL).
Official title: Malabsorption Blood Test (MBT) to Determine Exocrine Pancreatic Function and Related Quality of Life in Chronic Pancreatitis
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-03
Completion Date
2028-09
Last Updated
2026-02-18
Healthy Volunteers
No
Interventions
Pancreatic Enzyme Replacement Therapy
12 participants who are PERT responders in the MBT will be randomized to receive 8 weeks of PERT (144,000 lipase units daily)
Placebo
12 participants who are PERT responders in the MBT will be assigned to receive 8 weeks of placebo therapy
MBT1
MBT off PERT
MBT 2
MBT on PERT
Locations (2)
Johns Hopkins Medicine
Baltimore, Maryland, United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States