Clinical Research Directory

Role of RNA Metabolism Alterations in Persistent Immune Dysfunction After Sepsis

Sponsor: Assistance Publique - Hôpitaux de Paris

Summary

This study includes adult ICU patients with sepsis (according to SEPSIS 3.0) or critically ill non-septic patients with severe non-infectious conditions at Louis Mourier Hospital. It is a prospective multicentre observational study aiming to describe leukocyte transcriptome changes and molecular trajectories (endotypes) during the acute, recovery, and convalescence phases of sepsis. A total of 290 participants will be included: 200 septic patients, 50 critically ill non-septic patients, and 40 control participants.

Official title: Rôle Des Altérations Du Métabolisme De L'ARN Dans La Persistance Des Perturbations Immunitaires Au Décours Du Sepsis

Key Details

Conditions

Locations (2)