Clinical Research Directory

Inclusion Criteria: * Current primary DSM-5 OCD diagnosis and current Y-BOCS total score of ≥16 (OCD group, only) or no current diagnosis of an emotional disorder, and no known history of OCD, PTSD, anxiety disorder(s), or recurrent major depressive disorder (Healthy participant group, only) * 18-60 years of age * ability to speak, read, write, and understand English sufficiently well to complete study procedures and provide informed consent * psychotherapy and/or psychiatric medication use remain stable for 6 weeks prior to study entry Exclusion Criteria: * Presence of current psychiatric diagnosis (healthy control group, only) * active substance use disorder * history of mania or hypomania, or lifetime presence of significant psychotic symptoms * active suicidal or homicidal ideation * use of medications known to reduce seizure threshold (e.g., stimulants) * organic brain disease or injury representing a contraindication to TMS * any health problems that would interfere with safe and/or practical study participation, including contraindications to TMS (e.g., seizure disorder, presence of metal hardware that would come in close contact with the discharging coil) * current pregnancy or planning to become pregnant during the study period