Clinical Research Directory
Browse clinical research sites, groups, and studies.
Menopausal Hormones and Sympathetic Activation
Sponsor: University of Delaware
Summary
The purpose of this study is to understand how changes in menopausal hormones like estradiol and follicle-stimulating hormone (FSH) impact sympathetic nervous system function. To do so, the investigators will use a medication to control the production of estradiol and FSH, and in some participants, add-back estradiol to isolate its effects. The investigators will measure sympathetic activation centrally (in the brain using MRI), peripherally in the nervous system, and also examine adrenergic receptor mediated control of vascular function.
Official title: Impact of FSH and Estradiol on Sympathetic Function in Menopausal Women
Key Details
Gender
FEMALE
Age Range
40 Years - 58 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-09-01
Completion Date
2030-12-31
Last Updated
2026-03-27
Healthy Volunteers
Yes
Conditions
Interventions
Estrogen
Estradiol patch (0.1mg) All women will use a GnRH antagonist for 8 days. Some women will receive an estradiol patch for to wear on days 3-8, whereas other women will receive a placebo patch to wear on days 3-8. Measurements of sympathetic activation will occur on days 6-8.
Placebo
All women will use a GnRH antagonist for 8 days. Some women will receive an estradiol patch for to wear on days 3-8, whereas other women will receive a placebo patch to wear on days 3-8. Measurements of sympathetic activation will occur on days 6-8.