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RECRUITING
NCT07420530
EARLY_PHASE1

Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Motion

Sponsor: Indiana University

View on ClinicalTrials.gov

Summary

The overall objectives of the proposed research are to: 1. Evaluate the diagnostic validity of a novel mechano-acoustic signatures of task-characteristic activity during symptomatic and asymptomatic breathing in Exercise-Induced Laryngeal Obstruction (EILO) patients with the use of a novel miniature, soft wearable skin-mounted device, 2. Identify the mechanism/s of paradoxical respiratory control in EILO by quantifying the relationship between pulmonary mechanics, partial pressure of carbon dioxide (PCO2) maintenance, and vocal fold aperture prior to and during symptomatic and asymptomatic exercise ventilation, and 3. Identify unique biophysiological factors contributing to EILO among exercisers with and without EILO. Findings will be highly novel and clinically significant for early identification and management of EILO. For the study there are three separate visits: 1. Free running with the device on the neck 2. Exercise treadmill study 3. Undergoing MRI (Magnetic Resonance Imaging) of the vocal tract.

Key Details

Gender

All

Age Range

18 Years - 26 Years

Study Type

INTERVENTIONAL

Enrollment

120

Start Date

2026-04-20

Completion Date

2032-01-20

Last Updated

2026-03-02

Healthy Volunteers

Yes

Interventions

DRUG

Carbon Dioxide

Breathing Hypercapnic Gas (10% CO2 (carbon dioxide) and 21%O2 (oxygen), balance N210% (nitrogen))

BEHAVIORAL

Breathing treatment

Random Assignment to breathing conditions (rest breathing, rapid breathing, quick nasal sniff, pursed lip breathing), in a single blinded randomized design

Locations (1)

Indiana University

Bloomington, Indiana, United States