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Tacrolimus in Pregnancy
Sponsor: Baylor Research Institute
Summary
To create a formula that adjusts tacrolimus blood levels. This is needed because pregnant patients have higher levels of unbound tacrolimus. The adjusted formula will give a more accurate measure of the active drug in pregnant uterus transplant patients.
Official title: Optimization of Tacrolimus Management During Pregnancy: Modeling of Unbound and Whole Blood Tacrolimus in Pregnant Uterus Transplant Recipients
Key Details
Gender
FEMALE
Age Range
18 Years - 50 Years
Study Type
OBSERVATIONAL
Enrollment
55
Start Date
2026-03
Completion Date
2028-03
Last Updated
2026-02-25
Healthy Volunteers
Not specified
Conditions
Interventions
Modeling of unbound and whole blood tacrolimus in pregnant uterus transplant recipients
Develop an estimating equation to correct tacrolimus whole blood concentrations given the known increase in the unbound tacrolimus concentration in pregnant patients to obtain a more accurate picture of active tacrolimus exposure (unbound drug) in pregnant uterus transplant recipients.
Locations (1)
Baylor University Center of Dallas
Dallas, Texas, United States