Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Multi-site Study to Evaluate the Persistence of Protective Immunity to Routine Childhood Vaccinations in Participants With B-ALL/Ly Who Have Received Blinatumomab
Sponsor: Arkansas Children's Hospital Research Institute
Summary
The goal of this observational study is to establish a clear vaccination protocol for pediatric patients (less than 21 years old) who have received treatment for B-cell Acute Lymphoblastic Leukemia/Lymphoma. The main study aims are: * Evaluate the persistence of protective immunity to routine childhood vaccinations in participants with B-ALL/Ly who have received blinatumomab. * To determine whether revaccination in participants with non-protective titers leads to restored humoral immunity. Researchers will compare results from participants who have received immunotherapy to those who have not received immunotherapy to see if immunotherapy versus other chemotherapeutic drugs adversely affect the protective immunity acquired through vaccination.
Official title: Blinatumomab's Outcome On Serologic Titers and Efficacy of Revaccination
Key Details
Gender
All
Age Range
1 Year - 23 Years
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2026-01-13
Completion Date
2029-01
Last Updated
2026-02-25
Healthy Volunteers
No
Conditions
Locations (2)
Arkansas Children's
Little Rock, Arkansas, United States
Arkansas Children's Northwest
Springdale, Arkansas, United States