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Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy
Sponsor: Iuliu Hatieganu University of Medicine and Pharmacy
Summary
The goal of this clinical trial is to determine whether continuous nefopam administration, as part of a multimodal analgesia strategy, reduces opioid consumption and improves patient satisfaction after pancreatoduodenectomy. The main questions are: Does nefopam administration reduce opioid consumption after pancreatoduodenectomy? Does nefopam administration reduce postoperative pain levels after pancreatoduodenectomy? Researchers will compare two other analgesic strategies, namely continuous lidocaine infusion and epidural analgesia, to assess whether they lead to better outcomes. Participants will complete the QoR-15 questionnaire and report their pain levels at predefined time points before and after surgery.
Official title: Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy: A Randomized Controlled Double-Blind Trial
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
93
Start Date
2026-03
Completion Date
2026-10
Last Updated
2026-03-24
Healthy Volunteers
No
Interventions
Nefopam 120mg/day infusion
Nefopam administration will start in the intraoperative period and continue for 48 hours in the postoperative period
Lidocaine Infusion
Lidocaine infusion will begin in the intraoperative period and continue in the postoperative period for 48 hours
Peridural
This group will receive the stardad practice in our hospital, peridural analgesia alongside a multimodal analgesic approach involving paracetamol 4g/day
Multimodal IV analgesia
Standard postoperative multimodal pain management regimen
Locations (1)
Prof. O. Fodor Regional Institute of Gastroenterology and Hepatology
Cluj-Napoca, Cluj, Romania