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RECRUITING
NCT07424781
NA

Fluoxetine on Emotional Experience (FLEX) Study

Sponsor: University of Oxford

View on ClinicalTrials.gov

Summary

The goal of this clinical medicine study is to investigate how does antidepressant fluoxetine modulate anger processing in healthy young people . The main questions it aims is to answer are: 1. How does fluoxetine affect responses to anger-related stimuli such as words, faces, and autobiographical recall? 2. How does fluoxetine influence responses during frustration induction in frustrative non-reward and threat paradigms? 3. Does the effect manifest in physiological markers, including heart rate variability and facial expressions? Researchers will compare fluoxetine to a placebo to see if drug fluoxetine affects anger processing. Participants will: Take 20mg fluoxetine or a placebo every day for 7 days. Visit the university site for questionnaire and tasks assessments. Heart rate variability and facial expressions will be recorded in some of the tasks.

Official title: The Effect of Fluoxetine Treatment on Anger Processing in Healthy Young People

Key Details

Gender

All

Age Range

18 Years - 24 Years

Study Type

INTERVENTIONAL

Enrollment

80

Start Date

2025-10-01

Completion Date

2026-12-31

Last Updated

2026-02-20

Healthy Volunteers

Yes

Interventions

DRUG

Fluoxetine

Participants will receive 20mg of fluoxetine daily for 7 days. Tablets encapsulated to aid blinding.

DRUG

Placebo

Participants will receive one dose placebo (sucrose) daily for 7 days. Tablets encapsulated to aid blinding.

Locations (1)

Department of Psychiatry, University of Oxford

Oxford, Oxfordshire, United Kingdom