Clinical Research Directory
Browse clinical research sites, groups, and studies.
Attenuate the Stress Response in Laparoscopic Cholecystectomy
Sponsor: Assiut University
Summary
Aims of this study are to compare the effectiveness of dexmedetomidine versus fentanyl-midazolam in attenuating hemodynamic stress response during laparoscopic cholecystectomy (mainly HR). And to assess the recovery profile, the pain and opioid requirements, the sedation profile, and any adverse events during the first 24 hrs postoperatively
Official title: Dexmedetomidine Versus Fentanyl-Midazolam Combination to Attenuate the Stress Response in Laparoscopic Cholecystectomy
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2026-02
Completion Date
2027-04
Last Updated
2026-02-20
Healthy Volunteers
No
Conditions
Interventions
Dexmedetomidine
investigator will give Loading dose 1 mcg/kg IV over 10 min, followed by infusion 0.5 mcg/kg/h until pneumoperitoneum established
Fentanyl- midazolam
Investigator will inject Fentanyl 2 mcg/kg IV + Midazolam 0.05 mg/kg IV before induction.