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Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)
Sponsor: Attikon Hospital
Summary
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.
Official title: Association of Pre-operative Genicular Nerves Cryoneurolysis With Improved Pain and Function in Patients Undergoing Total Knee Arthroplasty
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2026-01-02
Completion Date
2028-03-31
Last Updated
2026-02-20
Healthy Volunteers
No
Conditions
Interventions
CT-guided Cryoneurolysis of the Genicular Nerves
Percutaneous CT-guided cryoneurolysis using up to three cryoprobes (-20°C to -100°C) for temporary sensory nerve interruption.
Locations (1)
Attikon University General Hospital
Athens, Greece