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Brillouin Scanning in Cataractous Eyes
Sponsor: Prim. Prof. Dr. Oliver Findl, MBA
Summary
To provide first results for biomechanical properties of cataractous lenses via Brillouin microscopy and correlations between LOCS III grading, cataractous lens scans from optical coherence tomography (OCT), and intraoperative phacoemulsification energy.
Official title: Pilot Evaluation of Cataractous Lens Stiffening Using a Brillouin Scanning Device
Key Details
Gender
All
Age Range
21 Years - 105 Years
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2025-03-11
Completion Date
2026-06-01
Last Updated
2026-02-23
Healthy Volunteers
No
Conditions
Interventions
Brillouin-Microscopy
A Brillouin scattering microscopy system (Brillouin Optical Scanning System, Intelon Optics, Boston, MA) will be employed to acquire data. The emission spectrum of the single-frequency tunable laser is fixed at approximately 780 nm near-infrared wavelength. Polarization optics direct the laser beam to the eye and channel backscattered light to a single-mode fiber at the human interface, where the laser light is transmitted over a polarization-maintaining single-mode fiber. To achieve a free-spectral range (FSR) of approximately 16 GHz, a resolution of approximately 0.3 GHz, and an extinction efficiency of -65 dB, the spectrometer employs dual-stage VIPA (virtually imaged phase arrays) etalons. The cornea's optical power is 3-5 mW, which is significantly lower than the utmost permissible exposure level as defined by the American National Standards Institute (ANSI).
Locations (1)
Vienna Institute for Research in Ocular Surgery (VIROS), Hanusch Hospital Vienna
Vienna, Austria