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Clinical Utility of ctDNA in the Treatment of Oligometastatic Disease
Sponsor: Aarhus University Hospital
Summary
This prospective observational study investigates the clinical utility of circulating tumor DNA (ctDNA) in patients with oligometastatic disease (OMD) undergoing definitive-intent local ablative treatment (LAT). The study aims to evaluate ctDNA as a prognostic and response biomarker before, during, and after LAT across cancer types and treatment modalities. Serial plasma samples and archival tumor tissue will be analyzed to assess ctDNA detection rates, elimination patterns, minimal residual disease, and association with recurrence, progression, and survival outcomes.
Official title: Clinical Utility of ctDNA in the Treatment of Oligometastatic Disease - A Prospective Observational Clinical Study - A Part of the POB-project
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
500
Start Date
2026-03-01
Completion Date
2030-09-01
Last Updated
2026-02-23
Healthy Volunteers
No
Conditions
Locations (1)
Department of Oncology, Aarhus University Hospital
Aarhus N, Denmark