Clinical Research Directory

* Inclusion Criteria: 1. Age ≥18 years at the time of study entry. 2. Patient with histologically documented early stage solid malignant tumor (NSCLC, head and neck cancer, melanoma (except uveal melanoma), bladder cancer or any other early stage solid tumor when I-O agent is expected to be efficient in a neo-adjuvant setting (whether in standard of care or within a clinical trial). 3. Patient for whom a neo-adjuvant treatment with immune checkpoint blockade including, but not limited to, anti-PD-1, anti-PD-L1 and anti-CTLA-4 mAb alone or in combination with chemotherapy or other therapies has been decided. 4. Availability of an archived tumor specimen (block FFPE) sampled prior to the start of the treatment. 5. Treatment with ICB not yet started. 6. ECOG Performance status 0-2. 7. Patient able to participate and willing to give informed consent prior to performance of any study-related procedures. 8. Patient affiliated to a Social Health Insurance in France. * Exclusion Criteria: 1. Patient pregnant, or breast-feeding. 2. Uveal melanoma 3. Any condition contraindicated with tumor /blood sampling procedures required by the protocol. 4. Known history of positive test for hepatitis B virus or hepatitis C virus or human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS). 5. Any current severe or uncontrolled disease, including, but not limited to ongoing or active infection and auto immune disorders. 6. Any psychological, familial, geographic or social situation, according to the judgment of investigator, potentially preventing the provision of informed consent or compliance to study procedure. 7. Patient who has forfeited his/her freedom by administrative or legal award or who is under guardianship.