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NOT YET RECRUITING
NCT07427251
PHASE4

The Postprandial Hypo-Avoid Study

Sponsor: Steno Diabetes Center Copenhagen

View on ClinicalTrials.gov

Summary

The objective of the study is to evaluate whether pre-exercise administration of low-dose subcutaneous glucagon prevents or attenuates exercise-induced declines in plasma glucose concentration during and after moderate-intensity continuous exercise (MICE) performed approximately 90 minutes after a meal in adults with type 1 diabetes using an automated insulin delivery (AID) system. The primary endpoint is the difference in the change in plasma glucose (PG) from exercise initiation to the nadir during exercise and through the 2-hour post-exercise period between the glucagon (GCN) and carbohydrate (CHO) visits.

Official title: Low-Dose Glucagon and Automated Insulin Delivery for Prevention of Spontaneous Exercise-Induced Hypoglycemia in People With Type 1 Diabetes

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

18

Start Date

2026-03-15

Completion Date

2028-05-01

Last Updated

2026-02-27

Healthy Volunteers

No

Interventions

DRUG

Low-Dose Glucagon

Participants will be given a low-dose of glucagon before starting the exercise session

DIETARY_SUPPLEMENT

Glucose Arm

Participants will be given a dose of glucose before starting exercise