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The Postprandial Hypo-Avoid Study
Sponsor: Steno Diabetes Center Copenhagen
Summary
The objective of the study is to evaluate whether pre-exercise administration of low-dose subcutaneous glucagon prevents or attenuates exercise-induced declines in plasma glucose concentration during and after moderate-intensity continuous exercise (MICE) performed approximately 90 minutes after a meal in adults with type 1 diabetes using an automated insulin delivery (AID) system. The primary endpoint is the difference in the change in plasma glucose (PG) from exercise initiation to the nadir during exercise and through the 2-hour post-exercise period between the glucagon (GCN) and carbohydrate (CHO) visits.
Official title: Low-Dose Glucagon and Automated Insulin Delivery for Prevention of Spontaneous Exercise-Induced Hypoglycemia in People With Type 1 Diabetes
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
18
Start Date
2026-03-15
Completion Date
2028-05-01
Last Updated
2026-02-27
Healthy Volunteers
No
Conditions
Interventions
Low-Dose Glucagon
Participants will be given a low-dose of glucagon before starting the exercise session
Glucose Arm
Participants will be given a dose of glucose before starting exercise