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Exploration of Circulating microRNAs as Biomarkers of Chemo-induced Peripheral Neuropathy: a Study in Cancer Patients
Sponsor: University Hospital, Clermont-Ferrand
Summary
This study aims to find out whether certain molecules in the blood, called microRNAs, are linked to how often and how severely people develop nerve damage from chemotherapy. The investigators will look at patients receiving cancer drugs known to affect the nerves, such as paclitaxel (used for lung cancer) and oxaliplatin (used for colorectal cancer).
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2026-01-29
Completion Date
2028-07-31
Last Updated
2026-02-23
Healthy Volunteers
No
Interventions
Assessment of blood concentrations of microRNAs
day 1, day 43, and day 155.
Chemotherapy-induced peripheral neuropathy (CIPN) - grade
day 1, day 43, and day 155.
Pain assessement
day 1, day 43, and day 155.
Assessment of blood concentrations of neurofilament light chain
day 1, day 43, and day 155.
Neuropathic pain assessment
day 1, day 43, and day 155.
Chemotherapy-induced peripheral neuropathy (CIPN) - severity
day 1, day 43, and day 155.
Locations (1)
CHU Clermont-Ferrand
Clermont-Ferrand, France