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Study of TGM-312-SC01 in Healthy Participants and Adults With MASH
Sponsor: Tangram Therapeutics Plc
Summary
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamic (PD) effects of single ascending doses of TGM-312-SC01 in healthy adults and multiple ascending doses in patients with metabolic dysfunction-associated steatohepatitis (MASH).
Official title: RESTORE-MASH: A Phase 1/2 Randomized, Placebo-Controlled Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of TGM-312-SC01 in Healthy Participants and Adults With MASH
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
99
Start Date
2026-02
Completion Date
2028-06
Last Updated
2026-03-27
Healthy Volunteers
Yes
Interventions
TGM-312-SC01
TGM-312-SC01 is an investigational medicinal product administered by subcutaneous injection according to a protocol-defined regimen.
Placebo
Placebo administered by subcutaneous injection according to a protocol-defined regimen.
Locations (1)
Clinical Site 1
London, United Kingdom