Clinical Research Directory

Inclusion Criteria (HEART Platform) * Participants are eligible for inclusion if they meet all of the following: * Age ≥18 years (or legal age of majority in participant's country of residence). * Diagnosis of heart failure, and eligible to be classified into one of the HEART platform states at the time of randomization: * State 1: Worsening Heart Failure (WHF): currently hospitalized for acute decompensated heart failure or emergency department patients requiring intravenous therapy for heart failure; OR * State 2: Ambulatory Heart Failure: stable outpatients with established heart failure diagnosis, receiving ongoing HF management and without HF hospitalization within the prior 30 days. * Able and willing to provide written informed consent (or consent via a legally authorized representative, where applicable). * Meets all applicable domain-specific eligibility criteria for at least one active HEART Platform domain at the time of screening/randomization. Exclusion Criteria (HEART Platform) * Participants will be excluded if any of the following apply: * Inability to provide informed consent (and no legally authorized representative available when applicable). * Not eligible for assignment to either HEART platform state (State 1 or State 2). * Presence of conditions or circumstances that, in the investigator's opinion, would make study participation unsafe or not feasible (e.g., inability to comply with study procedures or follow-up). * Does not meet the eligibility requirements for any active HEART Platform domain. * Any domain-specific exclusion criteria applicable to the intervention/domain(s) for which the participant would otherwise be eligible. * Additional inclusion and exclusion criteria apply for each individual HEART Platform domain and will be specified in the relevant domain protocol(s).