Clinical Research Directory
Browse clinical research sites, groups, and studies.
Which Rapid Sequence Induction Technique Should be Used in Urgent Surgery in Children?
Sponsor: Tunis University
Summary
The goal of our study is to compare classical Rapid Sequence Induction (RSI) and modified Rapid Sequence Induction (mRSI) in pediatric patients with a full stomach undergoing urgent surgical procedures. Due to reduced oxygen reserve in children, modified RSI incorporating gentle positive pressure ventilation has been proposed to reduce hypoxemia while maintaining protection against aspiration.
Key Details
Gender
All
Age Range
1 Month - 14 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2026-03-01
Completion Date
2026-09
Last Updated
2026-02-23
Healthy Volunteers
No
Interventions
Classical Rapid Sequence Induction
Patients received propofol (3-5 mg/kg) until loss of consciousness, followed by succinylcholine (1-2 mg/kg, adjusted for age). Tracheal intubation was performed 30 seconds after the completion of induction, without any positive pressure ventilation
Modified Rapid Sequence Induction
Patients received fentanyl (4 µg/kg), followed by propofol and succinylcholine at the same doses as in the RSI group. Following induction, patients received gentle positive pressure ventilation using the anesthesia machine in inspiratory support mode (inspiratory pressure: 10 cmH₂O; PEEP: 5 cmH₂O) for 30 seconds before tracheal intubation
Locations (1)
Bechir Hamza Children Hospital
Tunis, Bab Saadoun, Tunisia