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Pilot Study of Discarded Blastocysts
Sponsor: Igenomix
Summary
The goal of this observational study is to determine multiomics patterns related to global embryo quality to help overcome the limitations of conventional embryo quality assessment. The main question it aims to answer is: • Do discarded blastocysts that reach the blastocyst stage (days 5-6) show characteristic multiomics profiles which correlate with chromosomal abnormalities, providing insights into embryo viability? For that, patients undergoing an IVF treatment will be asked to donate their clinically discarded 5/6-day embryos (those that do not meet clinical criteria to be used for reproductive purposes). Participation in the study will not interfere with the planned IVF treatment. Patient participation is limited to signature of the informed consent to donate embryos and no other study-specific procedures will be performed on participants.
Official title: Prospective Observational Pilot Study of Discarded Blastocysts: a Molecular Approach to Uncovering Hidden Reproductive Potential
Key Details
Gender
FEMALE
Age Range
20 Years - 42 Years
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2026-02
Completion Date
2027-05
Last Updated
2026-02-24
Healthy Volunteers
No
Conditions
Interventions
Multiomics analysis
Donated discarded blastocysts (day 5/6) will undergo 2 TE biopsies and 1 ICM biopsy which will be analyzed for chromosomic status and multiomics profiles. Additional, when possible, cumulus cells and sper cells will also be analyzed. After donation of the discarded embryos, participants will follow their established IVF treatment.
Locations (1)
Oslo University Hospital HF (OUS HF), Rikshospitalet
Oslo, Oslo County, Norway