Inclusion Criteria:
1. Healthy male or female participants aged between 18 and 45 years (inclusive);
2. Male weight ≥ 50.0 kg, female weight ≥ 45.0 kg; body mass index (BMI) within the range of 19.0 to 26.0 kg/m² (including the threshold values);
3. Normal renal function (glomerular filtration rate calculated using the CKD-EPI equation ≥ 90 mL/min/1.73 m²);
4. Participants (including male participants) agree to have no plans for conception from screening until 3 months after the last dose, voluntarily adopt effective contraceptive measures, and have no plans for sperm or egg donation;
5. Participants fully understand the study purpose, nature, procedures, and potential adverse events, voluntarily agree to participate as subjects, can communicate well with the investigator, comply with all study requirements, and sign the informed consent form before the initiation of any study procedures.
Exclusion Criteria:
1. History of allergic diseases (e.g., asthma, urticaria, eczema, etc.), allergic constitution (e.g., allergy to two or more drugs), or known hypersensitivity to CS0159, rifampicin, itraconazole, or any excipients;
2. Participants with clinically significant findings, as judged by the investigator, of the following diseases (including but not limited to gastrointestinal, renal, hepatic, neurological, hematological, endocrine, oncological, pulmonary, immunological, psychiatric, or cardiovascular/cerebrovascular diseases) that may complicate protocol implementation or interpretation of study results, or whom the investigator considers to be at risk from participating in the study;
3. History of susceptibility to pruritus, or presence of conditions such as eczema/atopic dermatitis, neurodermatitis, psoriasis, or other diseases that may cause pruritus;
4. History of corrected QT interval (QTc) prolongation at screening:
1. QTc interval prolongation on 12-lead electrocardiogram (ECG) (QTcF ≥450 ms in males; QTcF ≥470 ms in females);
2. Family history of hypocalcemia or long QT syndrome.
5. History of acute or chronic bronchospasm (including treated or untreated asthma, chronic obstructive pulmonary disease);
6. Occurrence of an acute illness within 2 weeks prior to the first dose;
7. Presence of any known disease or condition that may interfere with drug absorption, distribution, metabolism, or excretion, including bile salt metabolism in the large intestine. Examples include inflammatory bowel disease, gastrectomy, cholecystectomy, etc.;
8. Use of drugs affecting hepatic metabolic enzyme function (e.g., barbiturates, carbamazepine, phenytoin, glucocorticoids, omeprazole, SSRIs, cimetidine, diltiazem, macrolides, nitroimidazoles, sedative-hypnotics, verapamil, fluoroquinolones, antihistamines) within 30 days prior to the first dose, or requirement for concomitant use of other drugs that may affect the absorption, distribution, metabolism, or excretion of the investigational drug during the study period;
9. History of blood donation within 3 months prior to the first dose, total blood loss ≥400 mL due to donation or other reasons within 6 months, or plans to donate blood during the study or within 3 months after study completion;
10. Current smokers, or participants unwilling to discontinue nicotine product use from 3 months before screening and during the study, or with positive urine cotinine test results;
11. Excessive consumption of tea, coffee, or caffeinated beverages (more than 8 cups per day, 1 cup = 250 mL) within 6 months prior to screening; or consumption of any food or beverage rich in caffeine and/or xanthine (e.g., coffee, strong tea, chocolate, caffeinated carbonated beverages, cola, etc.) from 48 hours before the first dose until the end of the study; or unwillingness to abstain from alcohol, fruit juice beverages, strenuous exercise, or other factors that may affect drug absorption, distribution, metabolism, or excretion;
12. Average weekly alcohol consumption exceeding 14 units (1 unit = 360 mL beer, 45 mL of 40% alcohol liquor, or 150 mL wine) in the past year, or inability to abstain from alcohol during the study, or alcohol breath test result \>0.0 mg/100 mL;
13. Drug abusers or participants with positive results on drug abuse screening (morphine, tetrahydrocannabinol acid, methamphetamine, methylenedioxymethamphetamine, ketamine, and cocaine);
14. Participation in another drug clinical trial within 3 months prior to this study (Note: The end date is defined as the date of discontinuation from the most recent clinical trial involving drugs or devices);
15. Positive screening results for hepatitis C virus antibody, hepatitis B surface antigen, HIV antibody, or syphilis treponemal antibody; abnormal liver function: AST, ALT, ALP, GGT, and TBil \> upper limit of normal (ULN);
16. Abnormal and clinically significant findings on physical examination, vital signs, laboratory tests, 12-lead ECG, or abdominal ultrasound at screening, as judged by the investigator;
17. Use of prescription or over-the-counter medications within 14 days prior to the first dose or within at least 5 half-lives (whichever is longer);
18. Use of any drugs or substances (e.g., herbal medicines, grapefruit, etc.) that may affect CYP3A activity within 14 days before taking the study drug and during the study period;
19. Difficulty swallowing, intolerance to venipuncture/indwelling needles, difficulty with blood sampling, history of needle or blood phobia, special dietary requirements, or inability to comply with standardized meals;
20. Any other conditions deemed unsuitable for participation by the investigator.
Additional exclusion criteria for female participants:
21. Use of oral contraceptives within 30 days prior to screening until randomization;
22. Use of long-acting estrogen or progestin injections (including progestin-containing intrauterine devices) or implants within 6 months prior to screening until randomization;
23. Unprotected sexual intercourse with a partner within 14 days prior to screening until randomization;
24. Positive pregnancy test;
25. Pregnant or breastfeeding females.
