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Exercise and Carotid Artery Function in Metabolic Syndrome
Sponsor: University of Wisconsin, Madison
Summary
The purpose of this study is to determine 1) if young adults with metabolic syndrome display endothelial dysfunction of the internal carotid artery in a sex-specific fashion and 2) if this endothelial dysfunction can be acutely improved with a single bout of exercise. This will be achieved by testing internal carotid artery function before and after a 30-minute bout of moderate intensity exercise. 48 young adults with and without metabolic syndrome will be enrolled and will be on study for approximately 5.5 hours over 4 study visits.
Official title: Identifying Sex-specific Carotid Endothelial Dysfunction in Young Adults With Metabolic Syndrome
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
OBSERVATIONAL
Enrollment
48
Start Date
2025-12-01
Completion Date
2027-06-30
Last Updated
2026-03-25
Healthy Volunteers
Yes
Conditions
Interventions
exercise
30 minute bout of cycling
Diagnostics
* Doppler Ultrasound used to non-invasively assess the diameter and blood flow going into an artery, the ICA in this study. * Indirect calorimeter in tandem with semi-recumbent bike used to assess O2 consumption * heart rate monitor
Inhaled CO2-mixed air
Three gases of different composition are used to ensure that the proper PETCO2 administration desired for this study occurs in tandem with keeping inspired O2 content constant. This is achieved by used a 5% O2, 95% CO2 tank, a 5% O2, 95% N2 tank, and a 100% O2 tank. In tandem, the use of these three tanks allows for precise control of PETCO2 without a change in inspired O2.
Locations (1)
University of Wisconsin
Madison, Wisconsin, United States