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The Effect of Muscle Stimulation and Amino Acid Intake on Protein Metabolism During Critical Illness
Sponsor: Wageningen University
Summary
The goal of this clinical trial is to study how whole-body electrical stimulation combined with amino acid intake affects muscle health in ventilated ICU patients. The main questions to answer are: * Does electrostimulation improve the balance of muscle protein in ICU patients? * Does combining electrostimulation with amino acid help build muscle and prevent muscle loss? Researchers will compare three groups of patients: 1. Sham electrostimulation (no current applied) + the standard nutrition 2. Electrostimulation + the standard nutrition 3. Electrostimulation + a 20g amino acid bolus Participants will: * Receive either real or sham electrostimulation * Get their standard nutrition or a 20g amino acid bolus * Have marked amino acids given through an IV * Have blood samples taken to measure the amino acids and glucose in the blood * Undergo ultrasound of the upper arm to measure the blood flow
Official title: The Effect of a Single Session of Whole-body Neuromuscular Electrical Stimulation (NMES), With or Without Subsequent Intake of an Amino Acid Bolus, on Whole-body Protein Turnover in Sedated Intensive Care Unit (ICU) Patients
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2026-02-18
Completion Date
2027-12
Last Updated
2026-02-24
Healthy Volunteers
No
Conditions
Interventions
Sham (No Treatment)
A placebo treatment in which no actual electrical stimulation is delivered, serving as a control for the active NMES.
NMES
Active neuromuscular electrical stimulation applied to the entire body to induce muscle contractions through small electric currents.
Amino acid bolus (20g)
A bolus dose of 20 grams of amino acids provided after the NMES intervention to assess the combined effect of muscle stimulation and protein intake on muscle protein metabolism.
Standard enteral nutrition
The provision of standard nutritional support, typically administered via enteral feeding tubes.
Locations (1)
Hospital Gelderse Vallei
Ede, Netherlands