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Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
Sponsor: AstraZeneca
Summary
The purpose of this study is to evaluate the efficacy and safety of sonesitatug vedotin in combination with capecitabine with or without rilvegostomig in first-line (1L) Claudin18.2 (CLDN18.2)-positive, human epidermal growth factor receptor 2 (HER2)-negative, gastric, gastroesophageal junction (GEJ), and esophageal adenocarcinoma.
Official title: A Phase III, Multicentre, Randomised Controlled Study of Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in First-Line Claudin18.2-Positive, HER2-Negative, Advanced/Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (CLARITY-Gastric 02)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
2130
Start Date
2026-02-03
Completion Date
2031-10-27
Last Updated
2026-02-24
Healthy Volunteers
No
Interventions
Sonesitatug vedotin
Intravenous
Rilvegostomig
Intravenous
Nivolumab
Intravenous
Capecitabine
Oral
5-Fluorouracil
Intravenous
Oxaliplatin
Intravenous
Zolbetuximab
Intravenous
Leucovorin
Intravenous
Locations (230)
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Phoenix, Arizona, United States
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Duarte, California, United States
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La Jolla, California, United States
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