Clinical Research Directory

Inclusion Criteria: * Participant must be 40 to 80 years of age inclusive at the time of signing the informed consent * Participants with stable CAD defined by coronary artery stenosis in any of the 3 main coronary vessels greater than 50 percent documented by coronary angiography within the last 36 months or history of myocardial infarction more than 6 months prior to the screening visit * Estimated glomerular filtration rate (eGFR) greater than or equal to 30 mL per min per 1.73 m2 at screening * Body weight greater than or equal to 60 kg and body mass index within the range greater than or equal to 18 and less than or equal to 36 kg per m2 at screening. Exclusion Criteria: * Ejection fraction less than 30 percent at screening as determined by echocardiography * Progressive angina with symptoms of worsening of angina in the 3 months prior to the first screening examination and/or interventions such as revascularization by percutaneous coronary intervention and or coronary artery bypass graft during the last 3 months * Documented current relevant coronary stenosis greater than or equal to 90 percent in any of the main 3 coronary vessels without bypass graft * Significant valvular heart disease with moderate or severe aortic stenosis or any other significant stenosis any other moderate or severe valvular failures hypertrophic obstructive cardiomyopathy * Symptomatic carotid stenosis or transient ischemic attack or stroke within 3 months prior to the first screening examination or patients with stroke at more than 3 months prior to the first screening examination with significant residual neurologic involvement * Atrial fibrillation pacemaker defibrillator atrial ventricular block II and III * History of sustained ventricular tachycardia or ventricular fibrillation within 12 months prior first screening visit * History of CNS diseases such as seizures neurodegenerative diseases * Lung diseases such as COPD GOLD stage 2-4 pulmonary arterial hypertension or asthma * Medical disorder condition or history of such that would impair the participant's ability to participate or complete the study in the opinion of the investigator.