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Boosting and Mapping Non-invasive Brain Stimulation Techniques
Sponsor: Ecole Polytechnique Fédérale de Lausanne
Summary
In this study we applied TMS to the hand area of M1 whilst acquiring fMRI of the brain. This study tested whether a higher-frequency form of brain stimulation, called high-gamma (100Hz) intermittent theta burst stimulation (iTBS), more effectively increases brain excitability than the standard 50Hz iTBS. In a double-blind, randomized study with 22 healthy participants, brain activity and motor responses were measured using TMS-fMRI. The 100Hz iTBS condition produced stronger and more consistent increases in motor excitability and greater activation of sensorimotor brain regions compared to 50Hz and sham stimulation, suggesting it may be a more effective approach for non-invasive neuromodulation.
Official title: Boosting and Mapping Non-invasive Brain Stimulation-induced Plasticity in Humans
Key Details
Gender
All
Age Range
18 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
22
Start Date
2023-02-02
Completion Date
2024-04-12
Last Updated
2026-09-22
Healthy Volunteers
Yes
Conditions
Interventions
Intermittent theta burst stimulation (iTBS) as a protocol of repetitive transcranial magnetic stimulation (rTMS)
iTBS applies a train of 3 pulses of stimulation, delivered at a gamma frequency, then repeated 10x at a theta repetition rate. Intensity of stimulation is personalized based on the individual's resting motor threshold, determined at the start of the session and delivered at 70% of this.
Locations (1)
Campus Biotech
Geneva, Canton of Geneva, Switzerland