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Comparison of Anti-Thrombotic Treatments Between Aspirin and Warfarin During Initial Six Months After Bioprpsthetic Heart Valve Replacement
Sponsor: Asan Medical Center
Summary
This trial is a multinational, multicenter, randomized, open-label, active-controlled clinical trial comparing the safety of aspirin versus vitamin K antagonists (warfarin) as oral antithrombotic therapy during the initial 6 months following tissue valve replacement (aortic or mitral).
Key Details
Gender
All
Age Range
19 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1058
Start Date
2026-02-01
Completion Date
2031-03-31
Last Updated
2026-02-25
Healthy Volunteers
No
Conditions
Interventions
Aspirin
100mg 1 tablet once daily for 6 months
Vitamin K antagonist(warfarin)
Maintain an INR of 2.0 to 3.0 for 6 months
Locations (3)
National Cerebral and Cardiovascular Center Hospital
Osaka, Japan
Osaka University Hospital
Osaka, Japan
Asan Medical Center
Seoul, South Korea