Clinical Research Directory

Patients will be included in the primary objective cohort for a given calendar year interval, if they satisfy the following inclusion and exclusion criteria within that year: Inclusion Criteria: * Observability (enrollment or activity) in the data source for at least one day during the patient identification period within that calendar year (set earliest qualifying date as "index date" for primary objectives) * Female sex at index date * Age ≥15 and ≤50 years at index date Exclusion Criteria: * (Primary Objective 1a only) Evidence of prior anifrolumab use in all available data prior to the index date through 1 day prior to the index date Patients will be included in the secondary objective cohort if they satisfy the following inclusion and exclusion criteria: Inclusion criteria * Receipt of anifrolumab therapy during the patient identification period (identify earliest record of anifrolumab in this period and set as "index date" for secondary objectives). * Female sex at index date. * Age ≥15 and ≤50 years at index date. * ≥180 days of continuous observability (e.g., enrollment or activity) in the dataset prior to and including the index date. * (For Secondary Objective 3 only) SLE diagnosis, defined as having at least one unique health care encounter record with an International Classification of Diseases, 10th Revision (ICD-10) code of M32\* (excluding M32.0: drug-induced SLE) within the 180-day baseline period prior to and including the index date. Exclusion criteria * Evidence of prior anifrolumab use in all available data prior the index date through 1 day prior to the index date.