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A Study to Learn About mRNA Vaccines Against Influenza in Adults
Sponsor: Pfizer
Summary
The purpose of this study is to learn about safety in participants taking the study vaccine (mRNA-based vaccine) and the ability of the study vaccine to trigger the body's immune response, targeting the flu virus (influenza virus). This study is seeking healthy participants 18 years of age or older. All participants in this study will receive only 1 dose in their arm, to deliver one of the experimental flu vaccines or one of the approved flu vaccines used for comparison. Participants will take part in this study for about 6 months, and participants will need to visit the study site at least 3 times. A blood sample will be taken at each of the 3 planned study visits and a swab from inside the nose will be taken at the first study visit.
Official title: A PHASE 2, RANDOMIZED, DOUBLE-BLIND, CLINICAL STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF MRNA VACCINES AGAINST INFLUENZA IN ADULTS 18 YEARS OF AGE AND OLDER
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
770
Start Date
2026-02-23
Completion Date
2027-06-22
Last Updated
2026-03-20
Healthy Volunteers
Yes
Conditions
Interventions
Vaccine Candidate #1
Investigational influenza Vaccine
Vaccine Candidate #2
Investigational influenza Vaccine
Vaccine Candidate #3
Investigational Influenza Vaccine
Vaccine Candidate #4
Investigational Influenza Vaccine
Vaccine Candidate #5
Investigational Influenza Vaccine
Vaccine Candidate #6
Investigational Influenza Vaccine
TIV1 or TIV2
Licensed influenza vaccine
Locations (15)
AMR Clinical
Mobile, Alabama, United States
Diablo Clinical Research, LLC d/b/a Flourish Research
Walnut Creek, California, United States
Clinical Research Consulting, LLC
Milford, Connecticut, United States
George Washington Medical Faculty Associates
Washington D.C., District of Columbia, United States
Indago Research & Health Center, Inc
Hialeah, Florida, United States
Palm Springs Community Health Center
Miami Lakes, Florida, United States
Clinical Research Atlanta
Stockbridge, Georgia, United States
East-West Medical Research Institute
Honolulu, Hawaii, United States
AMR Clinical
Kansas City, Missouri, United States
Rochester Clinical Research, LLC
Rochester, New York, United States
DM Clinical Research - Philadelphia
Philadelphia, Pennsylvania, United States
SMS Clinical Research LLC
Mesquite, Texas, United States
DM Clinical Research
Tomball, Texas, United States
J. Lewis Research, Inc. / Foothill Family Clinic
Salt Lake City, Utah, United States
Charlottesville Medical Research Center, LLC
Charlottesville, Virginia, United States