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Decoding Epigenetic Mechanisms Driving Immune Evasion in Liver Cancer With Omics Approaches
Sponsor: Niguarda Hospital
Summary
This is a national, observational, retrospective, cross-sectional, non-profit study focused on patients with HCC. The study aims to characterize the expression and function of novel noncoding regulatory transcripts, including those containing TEsin the microenvironment of liver tumors, with emphasis on their role in T cell dysfunction.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
270
Start Date
2026-01-01
Completion Date
2031-01-31
Last Updated
2026-02-27
Healthy Volunteers
No
Conditions
Interventions
Collection of tumor tissue (Fresh or/and archival FFPE), blood samples
NGS, immunofluorescence analyses, transcriptional and immunophenotypic analyzes, scRNAseq, ChIP-seq/ATAC-seq, DNA methylation, single-cell transcriptomic and TCR sequencing
Locations (1)
ASST GOM Niguarda
Milan, Lombardy, Italy