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Impact of Supplementation in Improving Metabolic Health Outcomes (ISMOS) Study
Sponsor: Institute for Human Development and Potential (IHDP), Singapore
Summary
This study investigates the role of multivitamin and multimineral (MVM) supplementation in improving metabolic, musculoskeletal, and mental health among midlife Asian women aged 40-60 years, a critical period marked by hormonal and physiological transitions from pre- to post-menopause. Evidence from the GUSTO cohort in Singapore has shown that higher plasma levels of vitamins B6, B9, B12, and D are associated with better metabolic profiles, insulin sensitivity, and mental wellbeing, while deficiencies are linked to increased metabolic and psychological risks. Given that vitamin insufficiency and central obesity are highly prevalent among Asian women even at lower BMI, this randomized, double-blind, placebo-controlled trial will evaluate whether 12 months of daily MVM supplementation can reduce MetaboAge and improve metabolic, mental, and muscle health outcomes compared with placebo. Findings will inform preventive strategies for extending health span and mitigating chronic disease risks among midlife women in Asia.
Key Details
Gender
FEMALE
Age Range
40 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2026-01-20
Completion Date
2028-01
Last Updated
2026-02-25
Healthy Volunteers
Yes
Interventions
Multivitamin/mineral study product
Participants will be randomised into one of the two study treatment arms
Locations (1)
Institute for Human Development and Potential (IHDP)
Singapore, Singapore