Inclusion Criteria:
* Male or Female adults ages 21-65 at the time of screening.
* Females of childbearing potential must have a negative pregnancy test at all designated visits.
* Have a self-reported interest in psychedelic drugs and altered states of consciousness.
* Never have used a classic, serotonergic psychedelic (such as psilocybin, psilocybin, LSD, or ayahuasca) or a dissociative anesthetic such as ketamine or PCP), or maximum one experience 5 years before the study starting without untoward effects.
* Participants must be free of current or past substance use dependence or disorders, as determined by a semi-structured clinical interview for DSM-5 diagnoses (SCID-DSM-5).
* Have a Body Max Index (BMI) 18-34 kg/m2 and an abdomen circumference ≤ 90 for women and 97 for men.
* In the investigator's opinion, participants are reliable and willing and able to comply with the protocol requirements and procedures.
* In addition to meeting the inclusion criteria outlined, it is important to develop a positive rapport between all individuals both participating in and coordinating the study.
Exclusion Criteria:
* Any psychiatric, cardiovascular, neurological, or other disorders that may be aggravated by participation in the study, or complicate interpretation of the study's results.
* Any substance use disorder.
* For women, a positive pregnancy test, or not using a reliable method of birth control.
* Personal or family history of severe psychiatric disorders (schizophrenia, bipolar disorder, addiction, ASD) and/or psychosis in the first and second degree.
* During the interview family history is asked in detail. Example: Did your parents or grandparents received a diagnosis of schizophrenia, bipolar disorder, depression.... Did somebody die by suicide? ...Did somebody was hospitalized in a psychiatric hospital? Did somebody in the family was judged "strange"? Different? Even if 40 years ago the diagnosis of depression or bipolar disorder was less precise, do you have the impression that somebody was sick?
* A resting blood pressure \> 140 systolic and 90 diastolic (mmHg).
* Cardiovascular diseases including valvulopathy.
* Current tricyclic antidepressant, lithium, SSRIs, first- and second-generation ketamine antipsychotics, or MAOI prescription regimen.
* Current dietary supplementation of 5-hydroxytryptophan and St. John's Wort.
* Medically significant condition rendering unsuitability for the study (e.g., diabetes, epilepsy, severe cardiovascular disease, hepatic or renal failure e.g. CLRC \< 30 ml/min etc.).
* History of serious suicide attempts requiring hospitalization.
* Significant history of mania (determined by study psychiatrist and medical records).
* Psychiatric condition judged to be incompatible with establishment of rapport with therapy team and/or safe exposure to psilocybin, e.g. borderline personality disorder.
* Blood or needle phobia.
* Participants who do not agree to use an acceptable contraceptive method throughout their participation in study.
* Use of contraindicated medication.
