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Impact of C-Mill Rehabilitation on the Gut-Brain Axis in Parkinson's Disease
Sponsor: IRCCS Centro Neurolesi Bonino Pulejo
Summary
The GM-REHAB-2025 study aims to evaluate the impact of physiotherapy interventions using the C-Mill treadmill, with and without semi-immersive virtual reality, on gut microbiota and metabolic parameters in patients with Parkinson's disease. Three groups will be involved: one undergoing conventional physiotherapy, one treated with the C-Mill without virtual reality (VR), and one treated with C-Mill technology combined with VR. Clinical assessments and the collection of biological samples (stool, serum, and plasma) will be carried out at three time points: at baseline, at the end of treatment (21 days), and after 3 months.
Official title: Gut-Brain Axis and Rehabilitation: Study on the Effects of C-Mill Technology on the Intestinal Microbiota of Parkinson's Disease Patients
Key Details
Gender
All
Age Range
40 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-10-20
Completion Date
2028-10-20
Last Updated
2026-02-25
Healthy Volunteers
No
Conditions
Interventions
C-Mill technology treadmill equipped with semi-immersive VR
C-Mill treatment combined with semi-immersive virtual reality (VR). The VR component will feature visual obstacles, such as virtual traffic cones or country paths, in conjunction with audio-visual stimuli to promote engagement and guide movement.
C-Mill treatment without semi-immersive virtual reality (VR)
C-Mill treatment will be administrated as a standalone therapy, without the integration of virtual reality (VR).
Conventional physiotherapy training
Will be carried under the manual guidance and supervision of a physiotherapist. The rehabilitation program will include weight-shifting exercises, as well as monopodal and bipodal balance exercises.
Locations (1)
Irccs Centro Neurolesi Bonino Pulejo
Messina, Messina, Italy