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Safety and Efficacy of Dexmedetomidine in Controlling Hemodynamics During Resection of Active Thyroid Secreting Tumors
Sponsor: South Egypt Cancer Institute
Summary
Experienced anesthesiologists often attempt to anticipate and blunt the hypertensive responses seen in varying degrees at critical moments of surgical stimulation. Additionally, it may take a long time to treat acute intraoperative hypertension using anesthetics, and there may be a subsequent period of hypotension due to over-compensation. Most practicing anesthesiologists rely on antihypertensive drugs for the rapid control of elevated arterial blood pressure, when volatile anesthetics and narcotics need to be discontinued for awakening. Relatively high doses of antihypertensive drugs, such as labetalol, nicardipine, or esmolol, are commonly used, regardless of the anesthetic technique.One of the main methods to control arterial blood pressure intraoperatively, was to use a typical antihypertensive regimen on an as-needed basis as well as common methods; adjustments in the concentration of volatile anesthetic.
Official title: Safety and Efficacy of Dexmedetomidine in Controlling Hemodynamics During Resection of Active Thyroid Secreting Tumors, A Randomized Multicentric Controlled Clinical Trial
Key Details
Gender
All
Age Range
20 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2024-04-25
Completion Date
2026-06-30
Last Updated
2026-02-25
Healthy Volunteers
No
Conditions
Interventions
Dexmedetomidine Injection [Precedex]
The study medications as dexmedetomidine and labetalol was prepared by an anesthesia assistant not involved in the study. A 50 ml syringe was filled with 50 μg dexmedetomidine diluted in normal saline solution in Dexmedetomidine group, while, 1 ml labetalol (50 mg) diluted in N.S solution in a 50 ml syringe for infusion in labetalol group was prepared.
Locations (1)
south Egypt cancer institute
Asyut, Egypt