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LRFN5 and OLFM4 in Bipolar Disorder
Sponsor: Elazığ Mental Health and Diseases Hospital
Summary
This cross-sectional observational case-control study evaluated serum levels of leucine-rich repeat and fibronectin type III domain-containing protein 5 (LRFN5) and olfactomedin-4 (OLFM4) in subjects with bipolar disorder (BD) during acute manic episodes and in healthy controls (HC). The study also assessed systemic inflammation using the Aggregate Index of Systemic Inflammation (AISI) and examined associations between biomarkers and clinical symptom severity, including Young Mania Rating Scale (YMRS) and Beck Depression Inventory (BDI) scores. The study aimed to investigate the potential interaction between synaptic dysregulation and immunoinflammatory abnormalities in BD.
Official title: Immunoinflammatory and Synaptic Biomarkers in Bipolar Disorder: A Case-Control Study of OLFM4 and LRFN5
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
72
Start Date
2025-07-07
Completion Date
2026-01-02
Last Updated
2026-06-29
Healthy Volunteers
Yes
Conditions
Locations (1)
Elazığ Mental Health and Diseases Hospital Psychiatry Clinic
Elâzığ, Elâzığ, Turkey (Türkiye)