Clinical Research Directory

Inclusion Criteria 1. Age ≥ 18 years 2. T2DM 3. CKD (eGFR ≥ 25-60 OR UACR ≥ 30 mg/g) 4. High Cardiovascular (CV) Risk: Defined as a history of prior myocardial infarction (MI), stroke, or peripheral artery disease (PAD), or the presence of cardiovascular risk factors, (specifically age 40 years or older and at least one of the following: cholesterol above target (LDL≥1.8 mmol/L OR on cholesterol lowering medication), hypertension (≥130/80 mmHg or on BPLMs), or atrial fibrillation.) 5. Open to start new medications Exclusion Criteria: 1. Type 1 diabetes 2. HbA1c ≥10% on screening labs 3. Serum potassium ≥ 5.2 mmol/L on screening labs 4. Baseline Blood Pressure (BP) \< 100/60 mmHg at screening 5. Treated with new or intensified immunosuppression therapy for new (or relapse/flare of pre-existing) kidney disease within the last 60 days 6. Kidney Transplant 7. Use of ≥3 medication classes: Participants already prescribed three or more of the following classes of medications: RASi, SGLT2i, nsMRA or GLP1RA 8. Intolerance or allergy to any of RASi, SGLT2i, nsMRA or GLP1RA 9. Known Heart Failure with Reduced Ejection Fraction (HFrEF) 10. Current pregnancy, lactation or women of childbearing potential, unless using highly effective contraception