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Iron Absorption From IFA and MMS Supplements in Kenyan Women During the Second Trimester of Pregnancy
Sponsor: ETH Zurich
Summary
This study evaluates iron absorption from three antenatal supplements, 30 mg MMS, 60 mg MMS, and 60 mg IFA, in 50 pregnant Kenyan women in their second trimester. Using a randomized crossover design and stable iron isotopes, we will compare bioavailability in both fasted and fed states. Additionally, the trial will investigate if daily dosing triggers a hepcidin response that inhibits subsequent absorption, testing whether alternate-day dosing is a more effective strategy for treating iron deficiency.
Official title: Comparing Iron Absorption From Multiple Micronutrient Supplements and Iron-folate Supplements: a Stable Isotope Study in Kenyan Pregnant Women
Key Details
Gender
FEMALE
Age Range
18 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2026-03-02
Completion Date
2026-12-31
Last Updated
2026-02-27
Healthy Volunteers
No
Conditions
Interventions
MMS with 30 mg iron
Multiple Micronutrient Supplementation (MMS) with 30 mg of iron given with ferrous fumarate isotope (54Fe, 57Fe, 58Fe)
MMS with 60 mg iron
Multiple Micronutrient Supplementation (MMS) with 60 mg of iron given with ferrous fumarate isotope (54Fe, 57Fe, 58Fe)
IFA with 60 mg iron
Iron Folic Acid (IFA) with 60 mg of iron given with ferrous sulphate isotope (54Fe, 57Fe, 58Fe)
Locations (2)
Kwale Sub County Hospital
Kwale, Kwale County, Kenya
Msambweni County Referral Hospital
Msambweni, Kwale County, Kenya