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Bupivacaine for Postoperative Pain After Laparoscopic Hysterectomy
Sponsor: Serkan Kumbasar
Summary
This prospective, randomized, single-blind controlled study aims to evaluate the effect of bupivacaine injection at trocar entry sites and the vaginal cuff on postoperative pain in patients undergoing total laparoscopic hysterectomy for benign gynecologic conditions. Postoperative pain after laparoscopic hysterectomy may arise from trocar insertion sites and surgical manipulation of the vaginal cuff. Local anesthetic infiltration may reduce somatic pain and improve early recovery. Eligible patients will be randomly assigned to either receive 0.5% bupivacaine injection at trocar sites and the vaginal cuff at the end of surgery or receive no local anesthetic injection (control group). All patients will receive standard postoperative analgesia. Postoperative pain will be assessed using the Visual Analog Scale (VAS) at 1, 2, 3, 6, 12, and 24 hours after surgery. Secondary outcomes include additional analgesic requirement, time to first mobilization, time to first flatus, length of hospital stay, and postoperative complications.
Official title: Effect of Trocar Site and Vaginal Cuff Bupivacaine Injection on Postoperative Pain in Patients Undergoing Total Laparoscopic Hysterectomy
Key Details
Gender
FEMALE
Age Range
35 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2025-08-28
Completion Date
2026-06-04
Last Updated
2026-03-10
Healthy Volunteers
No
Conditions
Interventions
Bupivacaine %0.5 (hyperbaric)
Participants undergoing total laparoscopic hysterectomy will receive 0.5% bupivacaine infiltration at the end of surgery. A total of 12 mL of 0.5% bupivacaine will be administered: 2 mL to each of the four trocar sites (total 8 mL) and 2 mL bilaterally to the vaginal cuff (total 4 mL) prior to trocar removal. All other perioperative management and postoperative analgesia protocols will be standardized.
Locations (1)
SBÜ Gaziosmanpaşa Training and Research Hospital
Istanbul, gaziosmanpaşa, Turkey (Türkiye)