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RECRUITING
NCT07438067
PHASE1/PHASE2

EBV-AST Cell Therapy for EBV-Related Diseases After Stem Cell Transplantation

Sponsor: Daihong Liu

View on ClinicalTrials.gov

Summary

This exploratory clinical study focuses on the use of EBV-AST cell infusion for treating EBV-DNA viremia following allogeneic hematopoietic stem cell transplantation (Allo-HSCT). The study aims to determine the maximum tolerated dose (MTD) or optimal biological dose (OBD) of EBV-AST cells and assess their safety, tolerability, and preliminary efficacy in treating EBV-DNA viremia. The study will involve a 3+3 dose escalation design to evaluate three different dosages of EBV-AST cell infusion. The study is expected to provide important insights into the clinical application of cell-based therapies for EBV infections.

Official title: A Prospective Exploratory Study of EBV-AST Cell Injection for the Treatment of EBV-Related Diseases After Allogeneic Hematopoietic Stem Cell Transplantation

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

18

Start Date

2025-03-26

Completion Date

2028-03-26

Last Updated

2026-02-27

Healthy Volunteers

No

Interventions

BIOLOGICAL

EBV-AST cell

EBV-AST (EBV-specific cell infusion) for the treatment of EBV-DNA viremia and prevention of PTLD in patients post-Allo-HSCT.

Locations (1)

Chinese PLA General Hospital

Beijing, China